Subject(s)
Clinical Trials as Topic , Exercise Therapy , National Institutes of Health (U.S.) , Post-Acute COVID-19 Syndrome , Research Support as Topic , Humans , National Institutes of Health (U.S.)/economics , National Institutes of Health (U.S.)/organization & administration , Post-Acute COVID-19 Syndrome/therapy , Research Support as Topic/methods , Research Support as Topic/organization & administration , United States , Exercise Therapy/adverse effectsABSTRACT
The mission of translational science is to bring predictivity and efficiency to the development and dissemination of interventions that improve human health. Ten years ago this year, the National Center for Advancing Translational Sciences was founded to embody, conduct, and support this new discipline. The Center's first decade has brought substantial progress across a broad range of translational areas, from diagnostic and drug development to clinical trials to implementation science to education. The origins of the translational science and advances to this point are reviewed here and allow the establishment of an ambitious future research agenda for the field.
Subject(s)
Translational Science, Biomedical/trends , History, 20th Century , History, 21st Century , Humans , National Institutes of Health (U.S.)/history , National Institutes of Health (U.S.)/organization & administration , Translational Science, Biomedical/history , Translational Science, Biomedical/organization & administration , United StatesSubject(s)
Communication , Leadership , National Institutes of Health (U.S.)/organization & administration , National Institutes of Health (U.S.)/trends , Politics , Science , Behavioral Research , Biomedical Research/organization & administration , Biomedical Research/trends , COVID-19/diagnosis , COVID-19/prevention & control , Federal Government , Fetal Research/legislation & jurisprudence , Gain of Function Mutation , Gene Editing/ethics , Gene Editing/legislation & jurisprudence , Humans , National Institutes of Health (U.S.)/legislation & jurisprudence , Risk-Taking , Science/trends , United StatesSubject(s)
Centers for Disease Control and Prevention, U.S./economics , National Institutes of Health (U.S.)/economics , Politics , United States Food and Drug Administration/economics , COVID-19/economics , COVID-19/prevention & control , Centers for Disease Control and Prevention, U.S./organization & administration , Humans , National Institutes of Health (U.S.)/organization & administration , United States , United States Food and Drug Administration/organization & administrationSubject(s)
COVID-19 , Diplomacy , Leadership , National Institutes of Health (U.S.)/organization & administration , Racism/prevention & control , Biomedical Research/economics , Biomedical Research/legislation & jurisprudence , Biomedical Research/organization & administration , COVID-19/complications , COVID-19/epidemiology , China , Female , Fetal Research/legislation & jurisprudence , Financing, Organized , Humans , International Cooperation , Male , National Institutes of Health (U.S.)/economics , Research Support as Topic , United States , Post-Acute COVID-19 SyndromeSubject(s)
Biomedical Research/organization & administration , Clinical Trials as Topic/organization & administration , Coronavirus Infections/epidemiology , Drug Industry/organization & administration , National Institutes of Health (U.S.)/organization & administration , Osteochondrodysplasias/drug therapy , Pneumonia, Viral/epidemiology , Animals , COVID-19 , COVID-19 Vaccines , Child , Coronavirus Infections/immunology , Coronavirus Infections/prevention & control , Drug Approval/organization & administration , Humans , Male , Osteochondrodysplasias/psychology , Pandemics , Stress, Psychological , Uncertainty , United States , Viral Vaccines/immunologyABSTRACT
Contemporary science has become increasingly multi-disciplinary and team-based, resulting in unprecedented growth in biomedical innovation and technology over the last several decades. Collaborative research efforts have enabled investigators to respond to the demands of an increasingly complex 21st century landscape, including pressing scientific challenges such as the COVID-19 pandemic. A major contributing factor to the success of team science is the mobilization of core facilities and shared research resources (SRRs), the scientific instrumentation and expertise that exist within research organizations that enable widespread access to advanced technologies for trainees, faculty, and staff. For over 40 years, SRRs have played a key role in accelerating biomedical research discoveries, yet a national strategy that addresses how to leverage these resources to enhance team science and achieve shared scientific goals is noticeably absent. We believe a national strategy for biomedical SRRs-led by the National Institutes of Health-is crucial to advance key national initiatives, enable long-term research efficiency, and provide a solid foundation for the next generation of scientists.